• If the lack of specificity and the

  2023-05-24

  

  If the lack of specificity and the high pleiotropy may represent a problem in view of the potential chemotherapeutic features of autophagy-inducing agents, it Tirapazamine may switch into an advantage in the case of chemopreventive strategies. In fact, as non-pharmacologic interventions such as limi

• The first description of autophagy as a tumour suppression

  2023-05-24

  

  The first description of autophagy as a tumour suppression process arises from the observation that the initial step regulatory gene, Atg6/BECN1, was monoallelically lost in 40% to 75% of human prostate, breast, and ovarian cancers [31]. However, while BECN1 heterozygous mutant mice develop, with lo

• br Discussion Herein we demonstrate that mice deficient in

  2023-05-24

  

  Discussion Herein, we demonstrate that mice deficient in L-12/15 LO are more sensitive to 3-NP-induced toxicity although a substantial individual variability in striatal lesion size in response to 3-NP in both genotypes was observed. This variability is not atypical; several studies demonstrate s

• A positive correlation between nasopharyngeal CCL and CCL

  2023-05-24

  

  A positive correlation between nasopharyngeal CCL3 and CCL5 [16] concentrations and illness severity was shown in evaluating patients with RSV bronchiolitis [17]. CCL5 and CCL3 are important for monocyte and lymphocyte recruitment to the lung during RSV infection [7], [16], [18]. Despite the signifi

• Several studies have demonstrated that depletion of function

  2023-05-24

  

  Several studies have demonstrated that depletion of functional ATR increases the sensitivity of cancer cells to oncogene-induced replication stress thereby hindering tumour growth and inducing extensive cell death (Gilad et al., 2010, Murga et al., 2011, Schoppy et al., 2012). Importantly, Schoppy e

• Another contributor for the G M arrest in A

  2023-05-24

  

  Another contributor for the G2/M arrest in A549 and H1299 cells might be p21WAF1/CIP1 which was up-regulated upon ovatodiolide treatment. p21WAF1/CIP1 is a common CDKs inhibitor which blocks silibinin receptor G2/M phase progression in various types of cancer cells (Kim et al., 2015, Liberio et al.,

• The apoptosis promoting Bcl family includes BH only proteins

  2023-05-24

  

  The apoptosis-promoting Bcl-2 family includes BH3-only proteins (e.g., Bim, Bid and Bad) and multiple-domain proteins (e.g., Bax and Bak). At the time of apoptosis stimulation (e.g., DNA damage), only the BH3-only protein is activated, directly or indirectly promoting Bax/Bak oligomerization, changi

• Available data thus indicate that

  2023-05-23

  

  Available data thus indicate that there are at least two ways that HMGA proteins can induce localized changes in the chromatin structure of inducible gene promoters, both of which involve positioned nucleosomes that must be “remodeled” before gene transcription can occur. The first mechanism is exem

• The application of diuretics induce an

  2023-05-18

  

  The application of diuretics induce an increased rate of water exiting brain cells encouraging the formation of increased intracellular polyphosphoric acid. In the absence of the diuretic water is retained in cells converting polyphosphoric WP 1130 to monophosphoric acid. The latter change decreases

• br Discussion In a series of linear

  2023-05-18

  

  Discussion In a series of linear mixed effects models of longitudinal neuroanatomical change, we have identified genetic risk variants associated with an increase in AICAR phosphate shape asymmetry in AD. The closest genes associated with significant SNPs include BIN1 (rs6733839), CD2AP (rs109483

• br Discussion In a series of linear

  2023-05-18

  

  Discussion In a series of linear mixed effects models of longitudinal neuroanatomical change, we have identified genetic risk variants associated with an increase in AICAR phosphate shape asymmetry in AD. The closest genes associated with significant SNPs include BIN1 (rs6733839), CD2AP (rs109483

• Thus we presumed that ALDH A might play an important

  2023-05-17

  

  Thus, we presumed that ALDH1A3 might play an important role in TMZ-chemoresistance in glioblastoma patients. As we expected, the glioblastoma cell lines and primary glioma SGX523 synthesis were more sensitive to TMZ treatment when ALDH1A3 was inhibited or depleted. Consistently, it has been shown th

• br Materials and methods br Results Dried leaves used were

  2023-05-17

  

  Materials and methods Results Dried Ampicillin Trihydrate synthesis used were 48.46 g C. benghalensis, 857.98 g T. zebrina and 25.09 g T. fluminensis. The samples gave 12.9% C. benghalensis, 0.078% T. zebrina and 3.06% T. fluminensis methanol extracts. The methanol extracts were evaluated fo

• We also show that in both

  2023-05-17

  

  We also show that in both ATM proficient and deficient/mutant glucose transporter the activation of ATR signaling is DSB complexity-dependent (Figs. 1, 4A, C and E, 6A and B). Wang et al. have also reported that the effects of ATR and CHK1 on radiosensitivity are independent of the NHEJ repair path

• br Materials and methods br Results br

  2023-05-17

  

  Materials and methods Results Discussion In the present study, we found that SSTR2, SSTR5, and DA2R proteins are expressed in ACTH-positive RF 9 in healthy canine pituitary glands, with particularly high positive cell ratios in the intermediate lobes. Somatostatin has been reported to inhi

14345 records 284/957 page Previous Next First page 上5页 281282283284285 下5页 Last page