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External factors such as protein partners
2021-04-06
External factors, such as protein partners, can also activate DUBs by either reinforcing the stimulatory effects of intramolecular factors or by other means. The intramolecular activation of the USP7 CD by its HUBL domain is allosterically potentiated by external factor GMP synthase (GMPS), which co
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In this study we have developed and investigated three NADPH
2021-04-06
In this study we have developed and investigated three NADPH-regenerating fusion partners with two different enzyme systems: a BVMO and an ADH. With the exception of one fusion construct (StGDH with LbADH), all fusion Pirarubicin receptor resulted in good soluble expression as well as fully functio
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br Enzymes involved in microbial steroid degradation are gen
2021-04-06
Enzymes involved in microbial steroid degradation are generally not expressed constitutively, but they are upregulated depending on which steroid substrates are present [17,81]. Thus, a cell-free extract prepared from testosterone-adapted C. testosteroni ATCC 11996 cells displayed a 1(2)-dehydroge
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One of the features of ROCO proteins controlled by
2021-04-06
One of the features of ROCO proteins, controlled by their domain architecture is their oligomerization status. By size-exclusion chromatography and Western blot analysis, DAPK1 was proved to form homodimers via its GTPase and kinase domains [53]. Similarly, Cell Counting Kit-8 microscopy studies co
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In the present study we combined
2021-04-06
In the present study, we combined activity-based protein profiling, biochemical and genetic approaches to identify the PLCPs involved in the sphingolipid pathway leading to plant PCD. By using Arabidopsis GSK J4 and leaves, we demonstrate that this sub-class of plant proteases is activated in respo
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hUcn II influence on MAP is mediated by
2021-04-06
hUcn II influence on MAP is mediated by the activation of CRF2 receptors. In vitro binding studies established that hUcn II is a selective ligand for CRF2 receptors with a slightly higher affinities for CRF2β compared with CRF2α and low or no affinity for CRF1 receptor [13], [19], [24]. Recent in vi
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Haggar et al reported the synthesis of
2021-04-06
Haggar et al. reported the synthesis of two new series of 8-(2-imino/oxo/thioxo pyrimidin-4-yl)-4-methyl-6-nitro-2-oxo-2H-chromen-7-yl benzoates 56 (X=O, S, NH) and 8-(pyrazol-3-yl)-4-methyl-6-nitro-2-oxo-2H-chromen-7-yl benzoates 57 [Y=C(O)CH3, 2,4-(NO2)2C6H3]. The 8-acetyl-4-methyl-6-nitro-2-oxo-2
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As the primary model we selected
2021-04-02
As the primary model we selected LDL-receptor knockout mice because these resemble the human plasma lipoprotein profile more closely. Currently, genetic models with reduced milk cholesterol content, which mimic cholesterol-free formula feeding, are unavailable. Thus, instead of modifying milk choles
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Initially studies of GPCRs predominantly
2021-04-02
Initially, studies of GPCRs predominantly assessed the signalling pathways downstream of receptors on the cell surface. There is now an understanding that GPCRs can localize to and signal from various intracellular compartments, such as the nucleus (reviewed in [40]). These intracellular pools of re
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Another enzyme class that has emerged as a potential
2021-04-02
Another enzyme class that has emerged as a potential alternative to P450s are the so-called ‘unspecific peroxygenases’ (UPOs). They also contain a heme but are extracellularly expressed fungal enzymes that are often more stable than P450 monooxygenases. Importantly, UPOs use H2O2 instead of O2 as th
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br Materials and methods br
2021-04-02
Materials and methods Results Discussion Fluoride has multiple effects that contribute to caries prevention. S. mutans is 20- to 40-fold more sensitive to NaF than Lactobacillus casei and seven-fold more sensitive than some species of Actinomyces[10]. There are some specific metabolic effec
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br Discussion The regulation of intracellular cholesterol le
2021-04-02
Discussion The regulation of intracellular cholesterol levels is a biological process of vital importance for cellular function and integrity, and involves robust transcriptional and post-transcriptional mechanisms that are sensitive to metabolic feedback control. Amongst post-transcriptional mec
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Historically covalent drugs have had great success
2021-04-02
Historically, covalent drugs have had great success (e.g., aspirin and penicillin), and covalent drugs have become a focus in anticancer and antiviral drug discovery (Kalgutkar and Dalvie, 2012, Singh et al., 2011). These compounds contain low reactivity warheads that allow covalent adducts to form
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br Restenosis after angioplasty remains a remarkable challen
2021-04-02
Restenosis after angioplasty remains a remarkable challenge, although drug-eluting stents have reduced the incidence of restenosis considerably . Vascular smooth muscle MP-470 australia (VSMCs) play a pivotal role in the development of intimal thickening and restenosis. VSMCs proliferate and migra
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Ubiquitination is a covalent attachment of
2021-04-02
Ubiquitination is a covalent attachment of 76 amino 1 78 ubiquitin molecules to target proteins, either as single moieties (mono-ubiquitination) or as poly-ubiquitin chains of different structures, formed through isopeptide bonds between specific lysines of one ubiquitin residue (for example K48, K6
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