• br Conclusions Enzyme can be delivered to the tumour by

  2020-11-23

  

  Conclusions Enzyme can be delivered to the tumour by using humanised or fully human KX2-391 dihydrochloride or even loaded into synthetic nanospheres produced from silica [64] or liposomally entrapped [65]. For any future ADEPT developments, a number of basic points need to be considered. As imm

• br Results and discussion br Conclusion br

  2020-11-23

  

  Results and discussion Conclusion Experimental section Pharmacological studies Introduction Survival analysis is a set of statistical methods that aim at modeling the relationship between a set of predictor variables and an outcome variable and, in particular, prediction of the time w

• Introduction The physiological significance of hypoxia is

  2020-11-23

  

  Introduction The physiological significance of hypoxia is undisputed, although largely over looked in the cancer therapeutics field focused on DNA-damage induced by ionizing radiation or drug treatment. Regions of hypoxia occur during a range of diverse biological situations including embryogenesis

• In the present study we investigated the effect of

  2020-11-23

  

  In the present study we investigated the effect of morphine withdrawal on G-protein coupling to opioid and ET receptors in neonatal rats. Morphine-induced G-protein activation was significantly higher in neonatal rats undergoing morphine withdrawal; suggesting enhanced coupling of the receptors to G

• br Materials and methods br Results

  2020-11-23

  

  Materials and methods Results Discussion In this study, the N&B analysis showed new evidence regarding the proportion and the oligomerization state of the AT1 and the ETA receptors near or on the plasma membrane. Althought, preliminary studies suggest that the AT1 and the ETA receptors occu

• NSC 66811 Prenylation may turn a flavonoid from

  2020-11-23

  

  Prenylation may turn a flavonoid from an agonist to an antagonist and improve the selectivity to both ERs depending on the position of the substitution. C-8 prenylation appears to promote antagonism to a larger extent than C-6 in ERα due to steric hindrance against generation of agonistic conformati

• In a study performed simultaneously by another

  2020-11-20

  

  In a study performed simultaneously by another group, EWS-FLI-1 introduction into unsorted murine bone marrow-derived BMS 309403 resulted in tumors with various phenotypes including one that is consistent with that of Ewing sarcoma [68]. The tumors expressed markers associated with Ewing sarcoma a

• The main advantage of exploiting paper

  2020-11-20

  

  The main advantage of exploiting paper sludges as sources of cellulose-derived energy and chemicals in comparison to other lignocellulose substrates is their amenability, which is associated with an extensive pulping process that removes the majority of the lignin and exposes bacteriological fibers

• Ample evidence has shown that ET

  2020-11-20

  

  Ample evidence has shown that ET-1 system plays a pivotal role in the development of cardiovascular anomalies and pharmacological inhibition of ETA prevents the development of cardiac hypertrophy [[37], [38], [39]]. Yanagisawa and coworkers, who first reported the cardiomyocyte-specific endothelin A

• br DDR receptor and MMP expression Type II collagen protein

  2020-11-20

  

  DDR2 receptor and MMP-13 expression Type II collagen protein in articular cartilage is highly stable structure as its half-life is 117 years [43]. The chondrocytes have limited ability to synthesis type II collagen protein in the matrix of mature articular cartilage once the collagen gets disrupt

• The strand domain swap in the UbV XR

  2020-11-20

  

  The β strand domain swap in the UbV.XR dimer appears to be a unique arrangement for a Ub-based dimer. In solution, free Ub has a KD of ∼5 mM for the monomer-dimer equilibrium, and the two subunits in the dimer adopt a range of relative orientations involving residues from Ub’s β sheet (Liu et al., 2

• br Results br Discussion The ubiquitin system has

  2020-11-20

  

  Results Discussion The ubiquitin system has in recent years become an exciting area for drug discovery (Cohen and Tcherpakov, 2010), as multiple enzymatic steps within the ubiquitylation process are druggable. The potential of targeting the ubiquitin-proteasome pathway was first demonstrated i

• Many studies reporting on discoveries of DUBs in the TGF

  2020-11-20

  

  Many studies reporting on discoveries of DUBs in the TGFβ and BMP pathways have relied on RNAi strategies to investigate loss-of-function impact. While RNAi strategies are useful tools, there are limitations ranging from limited knockdowns of targets to potential off-target effects. New and better t

• A recent study revealed that in human glioma cells

  2020-11-20

  

  A recent study revealed that in human glioma cells, DNA-PKcs interacted with the regulatory γ subunit of AMPK and positively regulated AMPK phosphorylation and activation under glucose-deprived conditions. This suggested that DNA-PK is an important regulator of AMPK activation in response to energy

• In the present study synthesis of Bi MoO nanoplates via

  2020-11-20

  

  In the present study, synthesis of Bi2MoO6 nanoplates via DNA-templated hydrothermal method has been undertaken. The synthesis was done through the hydrothermal method by means of the reaction of bismuth nitrate pentahydrate (Bi(NO3)3·5H2O) with sodium molybdate dihydrate (Na2MoO4·2H2O) precursor in

14336 records 720/956 page Previous Next First page 上5页 716717718719720 下5页 Last page